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SAMe Joint®


Joint Strength*

Liver Detoxification*

Mood and Brain Function*

About SAMe Joint®

Jarrow Formulas® SAMe Joint® provides a full 200 mg SAMe (net yield) and 525 mg of glucosamine hydrochloride in every enteric-coated tablet. SAMe Joint® is manufactured under low temperature and low humidity and is enteric-coated to ensure a biologically active product. SAMe and glucosamine are known to benefit joint function and recuperation.

Contains More of the Active S,S Form


Found in all living cells, SAMe is a metabolite of methionine (an essential amino acid). SAMe is a chiral molecule and consists of two forms: (S,S) SAMe and (R,S) SAMe. The biologically active form is the (S,S) structure, while the (R,S) structure is biologically inactive. Jarrow Formulas® SAMe is made naturally by microbiological fermentation and then specially processed without chemical solvents to preserve 68-80% (S,S) SAMe, the highest active level available. 


Glucosamine is an aminosaccharide synthesized by transamidase enzymes from glucose and an amine group from glutamine. HCl (hydrochloric acid) stabilizes the glucosamine in this product. Glucosamine is a component of joint and intestinal tissue and is involved in the production of synovial fluid that lubricates the joints.*  

SAMe has been clinically shown to have the following benefits:

Joint Strength*

SAMe supports the production of healthy connective tissue through transulfuration.* In this process, critical components of connective tissue, known as glycosaminoglycans (GAGs), including glucosamine and chondroitin, are sulfated by SAMe metabolites to yield sulfated GAGs, such as glucosamine sulfate and chondroitin sulfate.*

Brain Metabolism*

SAMe methylation reactions are involved in the synthesis of neurotransmitters such as L-DOPA, dopamine and related hormones, serotonin, epinephrine and phosphatidylcholine (a component of lecithin).* 


SAMe metabolism supports the synthesis of glutathione (GSH) and glutathione-dependent enzymes (glutathione peroxidase, glutathione reductase and glutathione-S-transferase), which are components of the body’s endogenous antioxidant network and important for liver function, including phase II detoxification.*

Jarrow Formulas® SAMe Joint® is foil blister-packed to maximize stability and safety. DO NOT use if seal of blister pack is broken. 

Full potency 200 mg SAMe (net yield) is derived from 400 mg of SAMe tosylate disulfate.

Jarrow Formulas® Glucosamine HCI is a SODIUM FREE form of glucosamine.

For best results, use with Jarrow Formulas® JarroSil®, the biologically Activated Silicon®.

Store in a cool, dry place.  

Keep out of the reach of children.

SAMe Joint®


Joint Strength*

Liver Detoxification*

Mood and Brain Function*

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SAMe Joint® Highlights

  • Enteric-Coated
  • 68-80% SAM-e in the Active S,S Form
  • Individually Blister-Packed
  • Supports Joint, Liver and Brain Health*

Product Details

Size: 60 Enteric-Coated Tablets

SKU: 790011200192

Product Code: SAMJNT-1

Detox & Liver Support, Joint Health, SAMe, Stress, Sleep & Mood

Suggested Usage

Take 1 tablet 1 or 2 times per day on an empty stomach or as directed by your qualified healthcare professional.

WARNING: Individuals using prescribed medications such as antidepressants, including Selective Serotonin Re-Uptake Inhibitors (SSRIs) and MAO Inhibitors should consult a physician before using this product. Individuals with Parkinson’s disease, bi-polar disorder or manic depression should not use SAMe. Do not use if pregnant or nursing. Do not exceed recommended intake. May cause gastrointestinal upset in some persons. If you experience discomfort, discontinue use.

Keep out of reach of children.

SAMe Joint® Supplement Facts

Other Ingredients

Cellulose, glyceryl behenate, medium chain triglycerides, oleic acid, sodium alginate, titanium dioxide, riboflavin, stearic acid (vegetable source), silicon dioxide, magnesium stearate (vegetable source), dextrin, dextrose and sodium citrate.

No wheat, gluten, soybeans, dairy, egg, fish/shellfish, or peanuts/tree nuts.

This product complies with the proposed USP Monograph for SAMe.

Suitable for vegetarians/vegans.

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